English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Hundreds of microRNAs (miRNAs) have been discovered in metazoans and plants, and understanding of their biogenesis has advanced dramatically; however, relatively little is known about the cofactors necessary for miRNA regulation of target gene expression. In  Caenorhabditis elegans , the conserved miRNA  let-7  and its paralogs, including  mir-84 , control the timing of stage-specific developmental events. To identify factors required for the activity of  mir-84  and possibly other miRNAs, we screened for mutations that suppress the developmental defects caused by overexpression of  mir-84 . Mutations in the  somi-1  gene prevent these defects without affecting the expression level of  mir-84 . Loss of  somi-1  also causes phenotypes similar to deletion of  mir-84 , showing that  somi-1  is necessary for the normal function of this miRNA.  somi-1  encodes a zinc finger protein that localizes to nuclear foci and binds the promoters of  let-60/RAS ,  lin-14 , and  lin-28 , genes that may be targeted by  mir-84  and similar miRNAs. Genetic evidence shows that  somi-1  inhibits  lin-14  and induction of the vulval precursors by the  let-60/RAS  pathway. Proteomic and genetic screens identified conserved chromatin-remodeling and homeodomain transcription factor complexes that work with  somi-1  to regulate differentiation. Our results suggest that  somi-1  coordinates a nuclear response that complements the activity of  mir-84 .

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA