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Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of   Genes  &amp;  Development , a new paper from Longworth and colleagues (1011–1024)  describes both physical and functional interactions between  Drosophila  Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates the Rb family proteins in mitotic chromosome condensation and suggests that a failure in targeting condensin II to chromatin underlies the aneuploidy in  rbf1  mutants.

pRb and condensin—local control of global chromosome structure