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Restricted expression of a mouse  Vasa  homolog gene ( Mvh ) expression is first detected in primordial germ cells (PGCs) after colonization of the genital ridges. Subsequently, Mvh  is maintained until postmeiotic germ cells are formed. Here, we demonstrate that male mice homozygous for a targeted mutation of  Mvh  exhibit a reproductive deficiency. Male homozygotes produce no sperm in the testes, where premeiotic germ cells cease differentiation by the zygotene stage and undergo apoptotic death. In addition, the proliferation of PGCs that colonize homozygous male gonads is significantly hampered, and OCT-3/4 expression appears to be reduced. These results indicate that the loss of Mvh  function causes a deficiency in the proliferation and differentiation of mouse male germ cells.

The mouse homolog of Drosophila Vasa is required for the development of male germ cells