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Caenorhabditis elegans mab-9  mutants are defective in hindgut and male tail development because of cell fate transformations in two posterior blast cells, B and F. We have cloned  mab-9  and show that it encodes a member of the T-box family of transcriptional regulators.  MAB-9  localizes to the nucleus of B and F and their descendents during development, suggesting that it acts cell autonomously in the posterior hindgut to direct cell fate. T-box genes related to  brachyury  have also been implicated in hindgut patterning, and our results support models for an evolutionarily ancient role for these genes in hindgut formation.

The Caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut