English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Notch signal transduction appears to involve the ligand-induced intracellular processing of Notch, and the formation of a processed Notch-Suppressor of Hairless complex that binds DNA and activates the transcription of Notch target genes. This suggests that loss of either Notch  or  Su(H)  activities should lead to similar cell fate changes. However, previous data indicate that, in the Drosophila  blastoderm embryo, mesectoderm specification requires  Notch  but not  Su(H)  activity. The determination of the mesectodermal fate is specified by Single-minded (Sim), a transcription factor expressed in a single row of cells abutting the mesoderm. The molecular mechanisms by which the dorsoventral gradient of nuclear Dorsal establishes the single-cell wide territory of  sim  expression are not fully understood. We have found that  Notch  activity is required for  sim expression in cellularizing embryos. In contrast, at this stage, Su(H)  has a dual function.  Su(H)  activity was required to up-regulate  sim  expression in the mesectoderm, and to prevent the ectopic expression of  sim  dorsally in the neuroectoderm. We have shown that repression of  sim transcription by Su(H) is direct and independent of  Notch activity. Conversely, activation of  sim  transcription by Notch requires the Su(H)-binding sites. Thus, Notch signalling appears to relieve the repression exerted by Su(H) and to up-regulate  sim transcription in the mesectoderm. We propose a model in which repression by Su(H) and derepression by Notch are essential to allow for the definition of a single row of mesectodermal cells in the blastoderm embryo.

genes and development

Repression by Suppressor of Hairless and activation by Notch are required to define a single row of <i>single-minded</i> expressing cells in the <i>Drosophila</i> embryo

Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo