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We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates.  nacre , a zebrafish homolog of  MITF , is required for pigment cell differentiation. We isolated a promoter region of  nacre  that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promoter binds to zebrafish Lef1 protein in vitro, and a  nacre  reporter construct is strongly repressed by dominant-negative Tcf in melanoma cells. Mutation of Tcf/Lef sites abolishes Lef1 binding and reporter function in vivo. Wnt signaling therefore directly activates nacre , which in turn leads to pigment cell differentiation.

Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway