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Organogenesis requires coordination between developmental specific regulators and genes governing cell proliferation. Here we show that Drosophila prospero  encodes a critical regulator of the transition from mitotically active cells to terminal differentiated neurons. Loss of  pros  results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity. In contrast, ectopic  pros  expression causes transcriptional suppression of multiple cell-cycle regulatory genes and premature termination of cell division.  pros  activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes.

Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis