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Genetic redundancy is associated with a large percentage of genes. We investigated  PTEN  (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene functions that eluded single mutant analyses, using a  Caenorhabditis elegans  genome-wide screen. We show that at least 27 genes collaborate with the worm  PTEN  homolog  daf-18  for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg laying, and oocyte maturation. In one example,  daf-18  appears to constitute a cell-autonomous germline signal that converges with a somatic gonad signal mediated by  ceh-18  at a kinase inhibition. We provide evidence that  daf-18  elicits some functions independent of the downstream gene  daf-16 .

Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development