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The RNA polymerases II and III snRNA gene promoters contain an octamer sequence as part of the enhancer and a proximal sequence element (PSE) as part of the core promoter. The octamer and the PSE bind the POU domain activator Oct-1 and the basal transcription factor SNAP c , respectively. Oct-1, but not Oct-1 with a single E7R mutation within the POU domain, binds cooperatively with SNAP c  and, in effect, recruits SNAP c  to the PSE. Here, we show that SNAP c  recruitment is mediated by an interaction between the Oct-1 POU domain and a small region of the largest subunit of SNAP c , SNAP190. This SNAP190 region is strikingly similar to a region in the B-cell-specific Oct-1 coactivator, OBF-1, that is required for interaction with octamer-bound Oct-1 POU domain. The Oct-1 POU domain–SNAP190 interaction is a direct protein–protein contact as determined by the isolation of a switched specificity SNAP190 mutant that interacts with Oct-1 POU E7R but not with wild-type Oct-1 POU. We also show that this direct protein–protein contact results in activation of transcription. Thus, we have identified an activation target of a human activator, Oct-1, within its cognate basal transcription complex.

genes and development

The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAP<sub>c</sub> largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1

The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1

The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAP_c largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1