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The development, growth, and survival of eukaryotic or-ganisms require the proper regulation of tens of thou-sands of genes. By complex formulae that have yet to be solved, the expression of each of these thousands of genes is controlled by a wide variety of mechanisms (e. g., see Lefstin and Yamamoto 1998; Roeder 1998; Struhl 1999; Glass and Rosenfeld 2000; Lee and Young 2000; Lemon and Tjian 2000; Strahl and Allis 2000; Courey and Jia 2001; Smale 2001; White 2001; Zhang and Rein-berg 2001; Emerson 2002; McKenna and O'Malley 2002; Narlikar et al. 2002; Orphanides and Reinberg 2002; West et al. 2002). In this review, we will focus on one of these regulatory components, the RNA polymerase II core promoter.

The RNA polymerase II core promoter: a key component in the regulation of gene expression