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.   Staphylococcus pseudintermedius , an opportunistic pathogen of dogs and cats, is rarely reported to cause infection in humans. Here, we describe a case of severe skin infection caused by  S. pseudintermedius , in a 47-year-old male, a dog owner; to the best of our knowledge, this is the first such case reported from Scotland.   Case presentation.  The patient presented with a short history of a severe ecthyma-like lesion on his forehead, with smaller lesions on his abdomen and legs. Bacterial culture revealed  Clostridium perfringens , thought to be colonizing the wound, and a  Staphylococcus  species, identified as  S. pseudintermedius  by matrix-assisted laser desorption/ionization-time of flight MS and confirmed by molecular methods using a PCR-RFLP approach. The patient was treated with flucloxacillin, penicillin V and Fucibet cream, and recovered fully. Zoonotic infection was considered likely; however, screening swabs from his dogs grew  S. pseudintermedius  of a different clonal type. Both patient and dog strains carried  Staphylococcus intermedius  exfoliative toxin and leucocidin I, closely related to Panton–Valentine leucocidin, possibly contributing to the severity of the infection.  S pseudintermedius , although coagulase positive, is normally negative by rapid slide clumping and latex agglutination tests routinely used to identify  Staphylococcus aureus . Hence,  S. pseudintermedius  may easily be misidentified as a coagulase-negative staphylococcus and considered insignificant.   Conclusion.  This is, to the best of our knowledge, the first reported case of a human  S. pseudintermedius  infection in Scotland. Zoonotic transmission of  S. pseudintermedius  between pets and owners has been shown. However, in this case zoonosis could not be confirmed.

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner