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Carbapenems have long been the dependable last line of treatment for multidrug‐resistant Gram‐negative bacteria.Case presentation:We report here two cases of enterotoxigenic Escherichia coli harbouring the New Delhi metallo‐β‐lactamase‐1 (NDM‐1) in childhood diarrhoea. Two paediatric patients aged 1.5 and 5 years were admitted to hospital with acute diarrhoea. The patients both had symptoms of fever, fatigue and anorexia. A molecular assay confirmed the presence of NDM‐1 in both the isolates.Conclusion:To our knowledge, this is the first report of NDM‐1‐producing enterotoxigenic E. coli in paediatric patients suffering from acute diarrhoea in the Andaman Islands and worldwide. Rapid molecular characterization of NDM‐1 of Enterobacteriaceae isolates needs to be undertaken in the future, especially when encountered with carbapenem resistance with conventional challenging, to tackle this public health problem.

New Delhi metallo‐β‐lactamase‐1 producing enterotoxigenic Escherichia coli in childhood diarrhoea from the Andaman Islands, India