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Fungitell (Associates of Cape Cod) is a new Food and Drug Administration-approved, commercially available assay for the detection of (1-3)-b-D-glucan (BG), a cell wall polysaccharide of a broad range of fungi, in clinical samples. The presence of BG in serum correlates clinically with certain invasive fungal infections (Odabasi et al., 2004; Ostrosky-Zeichner et al., 2005). However, there are very limited data on the use of Fungitell for serum BG detection to diagnose endemic mycoses. Amongst the dimorphic fungi associated with the endemic mycoses, Histoplasma capsulatum var. capsulatum and Blastomyces dermatitidis share a similar North American distribution. In the vast majority of individuals, infection will cause a transient influenza-like illness or can even be asymptomatic. In certain circumstances, these fungi can cause overt disseminated diseases. Detection of the infection can lag behind a clinically deteriorating patient, owing to inherent diagnostic difficulties (Faggi et al., 2001).

Observations on (1-3)-β-d-glucan detection as a diagnostic tool in endemic mycosis caused by Histoplasma or Blastomyces