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Carbenicillin was introduced in therapeutics in 1967 and was found to be particularly useful, either on its own or when associated with aminoglycosides, for the treatment of infections caused by Pseudomonas aeruginosa (Rolinson, 1998), a well-recognized nosocomial pathogen with intrinsic resistance to various antimicrobial agents and the ability to develop multidrug resistance. In 1969, a b-lactamase was found in P. aeruginosa Dalgleish. It was found to be ‘markedly active against carbenicillin’ and was named PSE-4 (Furth, 1975). Among the carbenicillin-inactivating b-lactamases, the CARB family is the main group and includes PSE-4 (CARB-1), PSE-1 (CARB-2), CARB-3, CARB-4, CARB-6, CARB-7, CARB-9 and N29, a b-lactamase from Proteus mirabilis. In addition, a new group of carbenicillinases, the RTG group, has been proposed, which includes RTG-1 (P. mirabilis GN79 enzyme), RTG-2 (CARB-5) and RTG-3. Although these three chromosomal enzymes show a low level of relatedness to members of the CARB family (44 %), they may be considered to be the ancestors of this enzymic group (Petroni et al., 2004). So far, four genotypes of blaCARB (blaCARB-1, blaCARB-2, blaCARB-3 and blaCARB-4) have been discovered in P. aeruginosa. We report on a multiple-drug-resistant P. aeruginosa strain from China carrying a CARB-like b-lactamase gene.

A CARB-like β-lactamase gene from a multiple-drug-resistant Pseudomonas aeruginosa clinical isolate in China