Open AccessAssociation between fluconazole susceptibility and genetic relatedness among Candida tropicalis isolates in Taiwan
Author(s) -
JangShiun Wang,
Shuying Li,
Yun-Liang Yang,
Hsiao-Hui Chou,
HsiuJung Lo
Publication year - 2007
Publication title -
journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.46664-0
Subject(s) - candida tropicalis , fluconazole , biology , microbiology and biotechnology , pulsed field gel electrophoresis , genotype , antifungal , genetics , gene
Among the 162 Candida tropicalis isolates collected in the Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 1999, 23 (14.2 %) had fluconazole MICs > or = 64 mg l(-1), and thus fulfilled the definition of resistance. Random amplified polymorphic DNA assay showed that all 23 fluconazole-resistance C. tropicalis isolates collected from different hospitals around Taiwan were closely related. Two distinct pulsotypes associated with fluconazole susceptibility were identified when these 23 resistant isolates, along with 13 susceptible ones, were analysed by PFGE.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom