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The AIDS pandemic is particularly serious in India where HIV-1 clade C is widely distributed (Sheppard et al. 1993). Attempts to generate a vaccine seem to have challenged the scientific community for over 25 years since the discovery of HIV-1. Conceptually the generation of any successful vaccine requires the understanding of features consistent to the virus and would depend on multiple factors including viral and host immunogenetic features as exemplified by HIV-1 infection. The preliminary characteristics necessary to define LTNPs in third-world countries especially in the Indian scenario are inadequate. Therefore we studied the virological microbiological and immunological characteristics of LTNPs (n=12) and progressors (n=12) with HIV-1 clade C infection at Y R Gaitonde Centre for AIDS Research and Education (YRG CARE) a tertiary HIV referral centre in Chennai South India. Since 1993 the centre has provided medical and psychosocial care to over 11000 HIV-infected individuals in the region and has been conducting vaccine and clinical trials in the south of India since 2001 and is funded by the National Institutes of Health and other organizations in the United States. YRG CAREs clinical and research laboratory has been participating in the external quality assessment programmes of the UK-National External Quality Assessment Scheme for immunophenotyping National Serology Reference Laboratory Australia and the College of American Pathologists USA and has been certified with Good Clinical Laboratory Practices compliance since 2001. (excerpt)

Laboratory characteristics of HIV-1 clade C-infected long-term non-progressors at a tertiary human immunodeficiency virus care centre in South India