Open AccessBiosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis
Author(s) -
C M Assis,
Rinaldo Ferreira Gandra,
Walderez Gambale,
M. T. Shimizu,
Claudete Rodrigues Paula
Publication year - 2003
Publication title -
journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.04933-0
Subject(s) - paracoccidioides brasiliensis , paracoccidioidomycosis , armadillo , hyaluronidase , microbiology and biotechnology , biology , paracoccidioides , dasypus novemcinctus , strain (injury) , enzyme , biochemistry , anatomy , ecology
The biosynthesis of chondroitinase and hyaluronidase by different isolates of Paracoccidioides brasiliensis was investigated in 20 strains isolated from patients (17 strains), a penguin (Pygocelis adeliae, one strain), an armadillo (Dasypus novemcinctus, one strain) and the environment (dog food, one strain). All the P. brasiliensis isolates studied had the ability to produce chondroitinase and hyaluronidase, although differences in colony morphology and enzyme production were detected among them. These results suggest that further investigations should be carried out in the clinical field in order to clarify the potential role of P. brasiliensis enzyme production in the pathogenesis of paracoccidioidomycosis.
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