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Scedosporium spp. are significant fungal pathogens in both immunocompromised and immunocompetent individuals. The effectiveness of antifungal therapy against Scedosporium spp. is limited due to their multidrug resistance to most widely used antifungal chemotherapies such as azoles, polyenes and echinocandins (Tortorano et al., 2014). Voriconazole, sometimes combined with surgery, appears to be the only drug significantly active against scedosporiosis. However, the mortality due to scedosporiosis remains high and finding more effective antifungal strategies is necessary. Antifungal combination treatment of drugs belonging to different classes may be a useful approach. So far, azoles in combination with echinocandins or polyenes or terbinafine, as well as polyenes in combination with other drugs, have been tested in vitro with various results (Afeltra et al., 2002; CuencaEstrella et al., 2008; Lackner et al., 2014; Meletiadis et al., 2003; Rodrı́guez et al., 2009; Troke et al., 2008; Yustes & Guarro, 2005).

In vitro activity of miltefosine in combination with voriconazole or amphotericin B against clinical isolates of Scedosporium spp.