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Bacterial cells are relatively simple entities with small, haploid genomes. Despite their simplicity, they are capable of coping with sudden and severe changes in the environment. This adaptability enables bacteria to colonize a wide range of ecological niches. When these niches are found on or within other living things, the bacteria may produce a pathological condition. The desire to obtain insights into the mechanisms by which bacteria cause disease has been a driving force in investigations of environmental adaptation by bacteria. The results of these investigations have revealed features which are common to many pathogenic and non-pathogenic organisms. These include an ability to sense changes in the external environment and to respond in an appropriate manner. This response frequently involves a change in the transcriptional profile of the cell as the expression of several genes is upor down-regulated simultaneously. This phenomenon implies that programmes exist in the cell for coordinated control of changes in transcription. The research efforts of my laboratory have been aimed at elucidating the molecular basis of this coordinated gene regulatory programme.

DNA topology and the global control of bacterial gene expression: implications for the regulation of virulence gene expression