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Meropenem, like imipenem, is a highly potent carbapenem antibiotic active against a broad range of bacteria including Pseudomonas aeruginosa [ 13. A study by Cooper and colleagues reported that zinc concentration in commercial media influenced the susceptibility of I? aeruginosa and other gram-negative bacilli to imipenem [2]. Similar results were reported by Daly et al. in 1997 [3]. We attempted to determine whether higher zinc concentrations in Mueller-Hinton agar (MHA) influence the zone diameters of meropenem and imipenem in the disk diffusion method.

Effect of zinc concentration in Mueller-Hinton agar on susceptibility of Pseudomonas aeruginosa to meropenem