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SUMMARY Transient (T) forms of Salmonella resemble both virulent smooth (S) and avirulent rough (R) forms. We studied the effect of the TI antigen on mouse virulence by introducing the rft+ gene, which determines the synthesis of TI- specific structures, into S and R forms. The TI antigen slightly increased the very low virulence of the R forms. When present together with the 0 antigen in TI, S hybrid forms the TI antigen had the opposite effect: it reduced the virulence of the S form considerably. This effect was probably due to the concomitant reduction in the amount of 0 antigen.

The Effect of T1 Antigen on the Virulence of Salmonella Strains for Mice