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SurmmaryRadioactive incorporation techniques have been employed to investigate the effect of isonicotinic acid hydrazide (INH) on biosynthetic reactions in Mycobacterium tuberculosis var. bovis BCG. INH has no measurable effect on incorporation of 32P phosphate, 35S sulphate or 14C glycine into whole cells, although it inhibits by 50% the incorporation of 14C acetate. Incorporation of 32P into trichloracetic acid (TCA) insoluble components of supernatant solutions from centrifuged disrupted bacteria appears to be inhibited soon after the cells are exposed to INH. Similar experiments with 35S show a lag of 30–40 hr before incorporation is influenced by the drug. Chemical fractionation of organisms grown in the presence of 32P show that the major effect of INH is exerted on incorporation into the ribonucleic acid fraction.

Effect of Isoniazid on Biosynthesis in Mycobacterium tuberculosis var. bovis BCG