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The inactivation of foot-and-mouth disease virus and vesicular stomatitis virus by long-lived inactivating agents in X-irradiated buffer solutions was investigated and compared with the findings of Alper (1952, 1955, 1956) relating to the inactivation of bacteriophage by similar agents. A comparison is made between the effects of these inactivating agents and of hydrogen peroxide to which there is a resemblance. Possible reaction kinetics are discussed in an attempt to explain the form of the survival curves resulting from such inactivation reactions. The radiation sensitization of the viruses to these modes of inactivation is also described and discussed.

The Influence of Previously X-irradiated Aqueous Solutions on the Infectivity of the Viruses of Foot-and-Mouth Disease and Vesicular Stomatitis