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SUMMARY: Pseudomonas aeruginosa strain C10 when exposed to phage Pc which had been inactivated by heat or acid produced a factor which decreased the yield of Pc phage in a single cycle of growth on P. aeruginosa C10. Some of the factor appeared in the culture fluid, but most could be obtained only by disrupting the bacteria. The factor did not inactivate free Pc phage. It decreased phage yield most when it was mixed with P. aeruginosa C10 1 hr. before infection with Pc phage and was then kept present to the end of the experiment. When the factor was diluted out immediately after adsorption of Pc phage on P. aeruginosa C10, or when it was present only from the start of adsorption, it had less effect on phage yield.

Interference with Multiplication of Pc Phage by a Factor Produced by Exposure of Pseudomonas aeruginosa to Inactivated Pc Phage