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SUMMARY: A significant extension in the variety of gene-markers available in Saccharomyces has been achieved by exploiting resistance and sensitivity to a variety of poisons. Although resistance to many poisons was obviously heritable, gene-control could not be demonstrated, presumably because other genes modified the phenotypes. Gene-control of resistance and sensitivity for both nicotine and caffeine was demonstrated by tetrad analysis and by the observation of regular Mendelian segregation of the characters among the progeny of closely related hybrids.

Gene Controlled Resistance and Sensitivity to Caffeine and Nicotine in Saccharomyces