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The authors report the isolation and molecular characterization of a bacteriophage, &amp;phi;CPG1, which infects CHLAMYDIA: psittaci strain Guinea pig Inclusion Conjunctivitis. Purified virion preparations contained isometric particles of 25 nm diameter, superficially similar to spike-less members of the &amp;phi;X174 family of bacteriophages. The single-stranded circular DNA genome of &amp;phi;CPG1 included five large ORFs, which were similar to ORFs in the genome of a previously described CHLAMYDIA: bacteriophage (Chp1) that infects avian C. psittaci. Three of the ORFs encoded polypeptides that were similar to those in a phage infecting the mollicute Spiroplasma melliferum, a pathogen of honeybees. Lesser sequence similarities were seen between two ORF products and the major capsid protein of the &amp;phi;X174 coliphage family and proteins mediating rolling circle replication initiation in phages, phagemids and plasmids. Phage &amp;phi;CPG1 is the second member of the genus CHLAMYDIAMICROVIRUS:, the first to infect a member of a CHLAMYDIA: species infecting mammals. Similarity searches of the nucleotide sequence further revealed a highly conserved (75% identity) 375 base sequence integrated into the genome of the human pathogen Chlamydia pneumoniae. This genomic segment encodes a truncated 113 residue polypeptide, the sequence of which is 72% identical to the amino-terminal end of the putative replication initiation protein of &amp;phi;CPG1. This finding suggests that C. pneumoniae has been infected by a phage related to &amp;phi;CPG1 and that infection resulted in integration of some of the phage genome into the C. pneumoniae genome.

microbiology

Microvirus of Chlamydia psittaci strain Guinea pig Inclusion Conjunctivitis: isolation and molecular characterization The GenBank accession number for the sequence reported in this paper is U41758.