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The aim of this investigation was to perform an extensive screening using HPLC and I3C-NMR spectroscopy to disclose the spectrum of osmolytes produced by aerobic heterotrophic and anoxygenic phototrophic eubacteria. The most predominant solutes detected within a wide range of marine and halophilic micro-organisms were two recently discovered tetrahydropyrimidines ectoine and hydroxyectoine, which were synthesized in response to osmotic stress.

The predominant role of recently discovered tetrahydropyrimidines for the osmoadaptation of halophilic eubacteria