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In Streptococcus faecium inhibition by both benzylpenicillin and cefotaxime of cells growing at maximal and at reduced rates was associated with saturation of different penicillin-binding proteins. Cells growing at reduced rates were not inhibited by benzylpenicillin concentrations that saturated all penicillin-binding proteins except penicillin-binding protein 5, but did stop growing when this protein was saturated.

In Streptococcus faecium Penicillin-binding Protein 5 Alone Is Sufficient for Growth at Sub-maximal But Not at Maximal Rate