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SUMMARY: Saccharomyces cerevisiae was grown in a glucose-limited chemostat at dilution rates equivalent to mass doubling times of 2 to 16 h. Phase contrast microscopy revealed that cultures with mass doubling times greater than 4.5 h contained two sub-populations of cells, phase-dark and phase-light. The latter were shown to be predominantly unbudded daughter cells, which were not proliferating, and had properties similar to those of stationary phase cells in batch culture. Phase-dark cells were equivalent to cells growing exponentially in batch culture. The results suggest that the formation of phase-light cells represents cell cycle specific differentiation into stationary phase. The consequences of this phenomenon for the interpretation of results obtained with S. cerevisiae in the chemostat are discussed.

Differentiation of Saccharomyces cerevisiae at Slow Growth Rates in Glucose-limited Chemostat Culture