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The analysis of molecular relationships among R factors and other plasmids of bacteria as well as the detection and characterization of extrachromosomal genes conferring resistance to antibiotics is possible by DNA-DNA hybridization. The amount of homologous polynucleotide sequences of plasmids can be assayed using the single-strand specific S l nuclease of Aspergillus oryzae (Crosa et al., 1973; Barth & Grinter, 1975). The endonuclease S1 method was used in this study to characterize genes specifying ampicillin resistance in bacteria isolated from hospital patients. The small plasmid RSF1030 which contains the TEM P-lactamase gene (Heffron et al., 1975) served as a molecular probe.

journal of general microbiology/journal of general microbiology

Characterization of Genes Specifying Ampicillin Resistance in Bacterial Isolates Using a Single-strand Specific Nuclease for Analysis of Plasmid DNA-DNA Duplexes