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The activity of adenylate cyclase (EC 4 .6 .1 . 1) in Escherichia coli and Salmonella typhimurium is thought to be inhibited when a carbon source is transported into the cell (Saier & Feucht, 1975; Saier et al., 1976; Harwood et al., 1976). This inhibition may be only apparent and may reflect a lack of activation of adenylate cyclase in this situation (Saier, 1977; Peterkofsky, 1977). With either mechanism, regulation of adenylate cyclase is thought to involve components of the phosphoenolpyruvate : sugar phosphotransferase system (PTS) (Postma & Roseman, 1976). Synthesis of adenylate cyclase also appears to be differentially repressed when cells grow with carbon sources causing minimal inhibition of adenylate cyclase activity (Peterkofsky et al., 1975; Pastan & Adhya, 1976). Growth of bacteria in a chemostat permits the concentration of limiting metabolites to approach zero in a steady state situation (Herbert et al., 1956). When carbon is limiting, the relevant transport system(s) become less saturated as the flow rate of fresh medium into the chemostat decreases. Consequently the inhibition of adenylate cyclase should be minimized while the putative activation of the enzyme should increase as the cells grow more slowly. Thus it would be expected that accumulation of cyclic AMP in the culture should increase at low dilution rates.

Synthesis of Adenosine 3':5'-Cyclic Monophosphate in Salmonella typhimurium Growing in Continuous Culture