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SUMMARY Antiserum was prepared in rabbits against purified haemagglutinin obtained from AO/BEL virus. The antiserum had potent virus-neutralizing and haemagglutina- tion-inhibiting activity, but was free of antibody to AO/BEL neuraminidase or to influenza A type-specific ribonucleoprotein. In immunodiffusion tests, the anti- haemagglutinin serum gave precipitin reactions with all Ao and A I virus strains tested but did not react with human A2 viruses or avian or porcine influenza A viruses. The studies suggested a close immunological relationship between the haemagglutinins of Ao and A r influenza viruses which was not revealed by haemagglutination-inhibition tests. I91

Studies with Antibody to the Purified Haemagglutinin of an Influenza Ao Virus