Open AccessNucleotide sequence of the herpes simplex virus type 2 gene encoding the protease and capsid protein ICP35
Author(s) -
Kevin Steffy,
Siegfried W. Schoen,
C M Chen
Publication year - 1995
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-76-4-1069
Subject(s) - capsid , biology , herpes simplex virus , gene , virology , nucleic acid sequence , open reading frame , peptide sequence , protease , virus , sequence analysis , microbiology and biotechnology , genetics , enzyme , biochemistry
The complete nucleotide sequence of the gene encoding the protease and ICP35 capsid protein of herpes simplex virus (HSV) type 2 strain G has been determined. The gene consisits of a 1908 bp open reading frame capable of encoding 636 amino acids. Comparative nucleotide sequence analysis of the gene with published HSV-1 sequences revealed that the HSV-2 nucleic acid segment most likely encodes two distinct proteins. The first protein is the HSV-2 protease, which is required for the assembly of the herpes virus capsid. The second protein has been previously designated as ICP35 in HSV-1, and belongs to the family of herpesvirus capsid proteins.
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