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Moloney murine sarcoma virus (Mo-MuSV) was one of the most widely studied mammalian retroviruses because it had acquired the cellular sequence called mos (Van Beveren et al., 1981a; Frankel & Fischinger, 1976), one of the first oncogenes identified. But difficulties with the low level of expression of the viral mos (v-mos) protein and apparent lack of cellular mos (c-mos) expression have decreased interest in Mo-MuSV. However, a variant of Mo-MuSV derived by mutagenesis and biological selection, ts110, clearly produces higher levels of a v-mos protein. The purpose of this review is to summarize important findings and properties of this system. Briefly, gag-mos proteins are produced in easily detectable amounts in cells infected with ts110 Mo-MuSV or in wild-type revertants derived from ts110 virus-infected cells. The ts110 mutant virus exhibits two conditional defects. One defect affects the production of the mRNA for the gag-mos protein and the other affects the stability of the gag-mos protein and its associated kinase function.

The ts110 Moloney Mouse Sarcoma Virus System: gag-mos Gene Products and Cellular Transformation