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Varicella-zoster virus glycoprotein gp1/gp3 was purified by affinity chromatography using anti-gp1/gp3 monoclonal antibody 19.1 linked to CNBr-activated Sepharose CL-4B. Rabbits immunized with purified glycoprotein gp1/gp3 developed mono-specific neutralizing antibody.

Affinity-purified Varicella-Zoster Virus Glycoprotein gp1/gp3 Stimulates the Production of Neutralizing Antibody