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Treatment of lymphocytic choriomeningitis virus with proteolytic enzymes, hyaluronidase, and phospholipase C increased infectious titres. Biochemical analysis of bromelain- and trypsin-treated virus revealed that infectivity was high in spite of the decrease to low or undetectable levels of all viral glycoproteins as well as partial degradation of the nucleoprotein.

Lymphocytic Choriomeningitis Virus. VII. Structural Alterations of the Virion by Treatment with Proteolytic Enzymes without Loss of Infectivity