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SUMMARY Two components, interferon and residual particles of input virus, con- tributed to the interfering activity recoverable from mouse embryo cultures treated with molluscum contagiosum virus. Physical and biological tech- niques were used to distinguish and allow the independent biological assay of each of these components. Cultural conditions greatly affected the induc- tion of interference by molluscum virus. Under optimal conditions, interferon was first detected in treated cultures 6 hr after virus adsorption, reached a maximal value at about i8 hr and then declined rapidly. Virus itself, dis- tinguished from interferon by its acid lability, sedimentability and failure to induce interference in L cells, declined rapidly in activity, during the early hours after adsorption to mouse embryo cells, to about 25 % of that calcula- ted to have been adsorbed. Although a direct correlation was not established between the amount of interferon produced and the decline in recoverable virus, a substantial part of this decline was interpreted as a significant biologi- cal event akin to 'eclipse' of infective virus in a permissive host.

Sedimentable and Non-sedimentable Interfering Components in Mouse Embryo Cultures Treated with Molluscum Contagiosum Virus