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The genome of a single cell derived from the B16 melanoma contains information for the expression of three distinct biologically active viruses: the N- and B-tropic ecotropic viruses and the xenotropic virus. Their release results in reduction of melanin production. A possible relationship of virus replication to differentiation may be involved.

Recovery of Three Distinct Biologically Active Type C Viruses from Cloned C57Bl/6 Melanoma Cells