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HBsAg antigenicity was found to be sensitive to periodate treatment. Antigenic determinants a and d were especially sensitive, losing almost all of their activity, while determinants r and w were found to be quite stable. Also, it is now possible to prepare the monospecific antibodies, anti-r and anti-w, by the use of this new, simpler procedure.

The Specific Reduction of a and d Antigenic Determinants after Periodate Treatment of Hepatitis B Surface Antigen (HBsAg)