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SummaryEvidence is presented that, in FV-3 infected BHK cell nuclei, the inhibition of RNA synthesis is paralleled by chromatin condensation. Inhibition of DNA synthesis could be due to the unavailability of the condensed chromatin to act as template.

Early Ultrastructural Changes Induced in BHK Cell Nuclei by Frog Virus 3. A Possible Mechanism for the Impairment of Cellular DNA Synthesis