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SUMMARY Chicks inoculated in the wing web with fixed rabies virus (RV) were protected against subsequent challenge injections of Rous sarcoma virus (RSV). The protec- tion was transient, generalized and was not elicited in birds treated with actino- mycin D or hydrocortisone. Chick serum was shown to possess a factor induced by RV, which inhibited RSV in vivo, and its presence in the serum at different times after RV administration was closely correlated with the RV-RSV blockade. This serum factor (SF), probably protein in nature, was heat and pH-labile. The inhibition of RSV by RV or the serum factor was affected by flock changes in a manner suggesting the occasional presence of interfering contaminating agent(s).

A Rabies-induced Serum Factor Inhibiting Rous Sarcoma Virus in Chicks