English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

SUMMARY Treatment of human cell cultures infected with herpes simplex virus type e (HSV- 2) with cytosine arabinoside resulted in the prevention of both virus cytopathology and synthesis of detectable infectious virus. Following removal of the inhibitor infectious HSV-2 reappeared and the cultures were destroyed. However, there was a delay of at least 5 to 6 days following inhibitor removal before infectious virus could be detected. The reappearance of infectious HSV-z was paralleled by virus cytopathology. The period between the disappearance and reappearance of infec- tious virus is defined as the latent period. Cultures during this period were as sensi- tive as control cultures to superinfection with HSV-z or vesicular stomatitis virus. Infectious centre assays performed with cultures during the latent period indicated that as many as I in 800 cells were capable of ultimately synthesizing infectious virus. Attempts to prevent the reappearance of infectious HSV-2 by treating infected cul- tures with cytosine arabinoside for up to 22 days were unsuccessful, thus indicating that HSV-2 can remain associated with the cells in a non-infectious form for an extended period without being degraded.

Herpes Simplex Virus Latency in Cultured Human Cells Following Treatment with Cytosine Arabinoside