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SummaryAn electron microscopic study was made of the plasma lactic dehydrogenase elevating virus of Riley et al. (1960) in cultures of mouse peritoneal macrophages. Four morphologically different forms of particle were seen: (1) large round particles, 510 A in diameter, consisting of a nucleoid enclosed by dense double membranes (310 A) and a less dense halo, which was occasionally seen to be bounded by a thin external membrane; (2) large elongated particles of similar morphology to type 1; (3) small round particles, 330 A in diameter, very similar in appearance to the nucleoid of the large particle; (4) small rod-shaped particles, also surrounded by double membranes and varying in length between 640 and 1240 A and in width between 200 and 380 A. Similar particles were observed in pellets prepared by ultracentrifugation from viraemic mouse plasma and the medium of infected cultures.

An Electron Microscopic Study of Lactic Dehydrogenase Virus in Cultures of Mouse Peritoneal Macrophages