Open AccessStudies on the antibacterial properties of some basic derivatives of cholane and norcholane
Author(s) -
Maurice Stacey,
Michael Webb
Publication year - 1947
Publication title -
proceedings of the royal society of london. series b, biological sciences
Language(s) - English
Resource type - Journals
eISSN - 2053-9193
pISSN - 0080-4649
DOI - 10.1098/rspb.1947.0030
Subject(s) - antibacterial activity , gram , chemistry , lactobacillus helveticus , lactobacillus casei , enterobacter aerogenes , hydrochloride , staphylococcus aureus , gram positive bacteria , microbiology and biotechnology , lactobacillus , bacteria , escherichia coli , biology , food science , biochemistry , organic chemistry , antimicrobial , fermentation , genetics , gene
A series of basic derivatives of cholane and norcholane has been examined for bacteriostatic activity against the Gram-positiveStaphylococcus aureus andLactobacillus helveticus and the Gram-negativeBacillus lactis aerogenes . The basic derivatives, in general, were more highly bacteriostatic against the Gram-positive organisms than against the Gram-negative. Of the compounds studied, the highest antibacterial activity was shown by 3:7:12-trihydroxy-23-guanido-norcholane hydrochloride. No relationship was apparent between the lowering of the surface tension of the medium induced by the compounds and their bacteriostatic activity.
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