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The effects of posterior lobe pituitary extract on the secretion and blood flow of the stomach have been demonstrated in the previous papers. As other substances capable of producing a vasoconstriction had a similar action, it was essential to establish whether the pituitary gland had any functional role in the intact animal which influenced secretion and blood flow. From the research of Krogh (1929) it would appear that in frogs the pituitary maintains a normal control over the capillaries. Gastric Secretion For these experiments tests have been conducted on cats having a permanent gastric fistula—these being comparable to the response of normal animals as previously shown. In most cases the normal reaction of these animals was first determined. Hypophysectomy was then performed by the buccal route under aseptic conditions ; ether or “ Nembutal ” being used for the anaesthetic. Following the operation the animals lived in a room kept at a constant temperature of 78°F. Control experiments have shown that this temperature did not appreciably alter secretion produced by the stimuli employed. Post-mortem examination of these animals included careful inspection and sectioning of the endocrine organs and sella—in many cases serial sections of the pituitary fossa and overlying brain were made.

Pituitary control of alimentary blood flow and secretion - Gastric secretion and blood flow in hypophysectomized animals