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A model simulating transport of dense core vesicles (DCVs) in type II axonalterminals of Drosophila motoneurons has been developed. The morphology of typeII terminals is characterized by the large number of en passant boutons. Thelack of both scaled up DCV transport and scaled down DCV capture in boutonsresults in a less efficient supply of DCVs to distal boutons. Furthermore, thelarge number of boutons that DCVs pass as they move anterogradely, until theyreach the most distal bouton, may lead to the capture of a majority of DCVsbefore they turn around in the most distal bouton to move in the retrogradedirection. This may lead to a reduced retrograde flux of DCVs and a lack of DCVcirculation in type II terminals. The developed model simulates DCVconcentrations in boutons, DCV fluxes between the boutons, age densitydistributions of DCVs, and the mean age of DCVs in various boutons. Unlikepublished experimental observations, our model predicts DCV circulation in typeII terminals after these terminals are filled to saturation. This disagreementis likely because experimentally observed terminals were not at steady-state,but rather were accumulating DCVs for later release. Our estimates show thatthe number of DCVs in the transiting state is much smaller than that in theresident state. DCVs traveling in the axon, rather than DCVs transiting in theterminal, may provide a reserve of DCVs for replenishing boutons after arelease. The techniques for modeling transport of DCVs developed in our papercan be used to model the transport of other organelles in axons.

Modeling transport and mean age of dense core vesicles in large axonal arbors