English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The ability of cells to reorganize in response to external stimuli isimportant in areas ranging from morphogenesis to tissue engineering. Elongatedcells can co-align due to steric effects, forming states with local order. Weshow that molecular-scale substrate anisotropy can direct cell organization,resulting in the emergence of nematic order on tissue scales. To quantitativelyexamine the disorder-order transition, we developed a high-throughput imagingplatform to analyze velocity and orientational correlations for severalthousand cells over days. The establishment of global, seemingly long-rangedorder is facilitated by enhanced cell division along the substrate's nematicaxis, and associated extensile stresses that restructure the cells' actomyosinnetworks. Our work, which connects to a class of systems known as active drynematics, provides a new understanding of the dynamics of cellular remodelingand organization in weakly interacting cell collectives. This enablesdata-driven discovery of cell-cell interactions and points to strategies fortissue engineering.

Molecular-scale substrate anisotropy and crowding drive long-range nematic order of cell monolayers