English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Using a stochastic individual-based modelling approach, we examine the rolethat Delta-Notch signalling plays in the regulation of a robust and reliablesomite segmentation clock. We find that not only can Delta-Notch signallingsynchronise noisy cycles of gene expression in adjacent cells in the presomiticmesoderm (as is known), but it can also amplify and increase the coherence ofthese cycles. We examine some of the shortcomings of deterministic approachesto modelling these cycles and demonstrate how intrinsic noise can play anactive role in promoting sustained oscillations, giving rise to noise-inducedquasi-cycles. Finally, we explore how translational/transcriptional delays canresult in the cycles in neighbouring cells oscillating in anti-phase and westudy how this effect relates to the propagation of noise-induced stochasticwaves.

Intrinsic noise, Delta-Notch signalling and delayed reactions promote sustained, coherent, synchronised oscillations in the presomitic mesoderm