Neutron scattering: a tool to detect in vivo thermal stress effects at the molecular dynamics level in micro-organisms | Zendy

Vincent Marty | Zendy; Marion Jasnin | Zendy; E. Fabiani | Zendy; Pierre Vauclare | Zendy; Frank Gabel | Zendy; Marcus Trapp | Zendy; Judith Peters | Zendy; Giuseppe Zaccaı̈ | Zendy; Bruno Franzetti | Zendy

Open Access

Neutron scattering: a tool to detect in vivo thermal stress effects at the molecular dynamics level in micro-organisms

Author(s) -

Vincent Marty,

Marion Jasnin,

E. Fabiani,

Pierre Vauclare,

Frank Gabel,

Marcus Trapp,

Judith Peters,

Giuseppe Zaccaı̈,

Bruno Franzetti

Publication year - 2013

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2013.0003

Subject(s) - molecular dynamics , neutron scattering , in vivo , biophysics , softening , halobacterium salinarum , protein dynamics , neutron , dynamics (music) , characterization (materials science) , scattering , chemistry , materials science , chemical physics , nanotechnology , biology , biochemistry , physics , optics , nuclear physics , computational chemistry , genetics , archaea , gene , acoustics , composite material

International audienceIn vivo molecular dynamics in Halobacterium salinarum cells under stress conditions was measured by neutron scattering experiments coupled with microbiological characterization. Molecular dynamics alterations were detected with respect to unstressed cells, reflecting a softening of protein structures consistent with denaturation. The experiments indicated that the neutron scattering method provides a promising tool to study molecular dynamics modifications in the proteome of living cells induced by factors altering protein folds

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