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S hypoglycemia (SH) is believed to be responsible for 4% to 10% of deaths in individuals with type 1 diabetes (T1D). Treatment recommendations for people with SH and impaired awareness of hypoglycemia (IAH) incorporate a tiered, 4-stage algorithm that includes educational, technological, and transplantation interventions. However, applicability of islet transplantation is restricted by limited supply of donor organs, need for immunosuppression, and strict eligibility criteria. This is the first report of mortality in people referred to a national islet transplantation program, whether or not they received a transplant.

Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation